 |
In the case of drug development, structural information of proteins involved in disease pathways is crucial for downstream rational design of novel therapeutics. The field of structural biology is currently undergoing a renaissance due to significant advances in cryogenic electron microscopy (cryo-EM) following the emergence of direct electron detectors and advanced computational platforms. Cryo-EM also allows the user to fix each sample in a biologically relevant buffer composition, enabling structural determination of some of the most elusive proteins and protein complexes which have been incapable of analysis through standard crystallographic techniques. Download the whitepaper to learn more! |
